MED SURG 102 Study Guide - Cancer Medications
Medication class: Colony-stimulating factors
Pharmacological action: Glycoprotein that binds to and stimulates neutrophils to divide and differentiate. also activates mature neutrophils. Binding to a polyethylene glycol molecule prolongs its effects.
Therapeutic use: Decreased incidence of infection in patients who are neutropenic from chemotherapy.
Adverse effects: Adult Respiratory Distress Syndrome (ARDS), splenic rupture, glomerulonephritis, sickle cell crisis, leukocytosis, medullary bone pain, anaphylaxis, capillary leak syndrome.
Contraindications: Hypersensitivity to filgrastim Escherichia -coli-derived proteins.
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