1.The nurse is caring for a patient who is receiving an intravenous antibiotic. The nurse notes that the provider has ordered serum drug peak and trough levels. The nurse understands that these tests are necessary for which type of drugs?
a.Drugs with a broad spectrum.
b.Drugs with a narrow spectrum
c.Drugs with a broad therapeutic index
d.d. Drugs with a narrow therapeutic index*
*Medications with a narrow therapeutic index have a limited range between the therapeutic dose and a toxic dose. It is important to monitor these medications closely by evaluating regular serum peak and trough levels.
2.The nurse is caring for a patient who is receiving an intravenous antibiotic. The patient has a serum drug trough of 1.5 mcg/mL. The normal trough for this drug is 1.7 mcg/mL to 2.2 mcg/mL. What will the nurse expect the patient to experience?
a.Inadequate drug effects*
b.Increased risk for superinfection
c.Minimal adverse effects
d.Slowed onset of action
*Low peak levels may indicate that the medication is below the therapeutic level. They do not indicate altered risk for superinfection, a decrease in adverse effects, or a slowed onset of action.
3.The nurse is teaching a nursing student about the minimal effective concentration (MEC) of antibiotics. Which statement by the nursing student indicates understanding of this concept?
a."A serum drug level greater than the MEC ensures that the drug is bacteriostatic."
b."A serum drug level greater than the MEC broadens the spectrum of the drug."
c."A serum drug level greater than the MEC helps eradicate bacterial infections."*
d."A serum drug level greater than the MEC increases the therapeutic index."
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